Trim62 Gene Summary [Mouse]
Predicted to enable identical protein binding activity; transcription coactivator activity; and ubiquitin protein ligase activity. Involved in positive regulation of antifungal innate immune response. Acts upstream of or within negative regulation of epithelial to mesenchymal transition. Predicted to be active in cytoplasm. Is expressed in several structures, including central nervous system; genitourinary system; maxillary process; sensory organ; and submandibular gland primordium. Orthologous to human TRIM62 (tripartite motif containing 62). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Trim62 |
| Official Name | tripartite motif-containing 62 [Source:MGI Symbol;Acc:MGI:1914775] |
| Ensembl ID | ENSMUSG00000041000 |
| Bio databases IDs | |
| Aliases | tripartite motif-containing 62 |
| Synonyms | 6330414G21Rik, DEAR1, tripartite motif-containing 62 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Trim62 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Cortexillin I, coiled coil
- coiled-coil (CC) domain of Drosophila brain tumor (brat) and similar proteins
- transcription co-activator
- B-Box C-terminal domain
- SPRY domain
- zinc finger of C3HC4-type, RING
- ubiquitin protein ligase activity
- Uso1 / p115 like vesicle tethering protein, C terminal region
- enzyme
- Ring finger domain
- protein binding
- identical protein binding
- associated with SPRY domains
- ZW10 interactor
- B-box-type zinc finger superfamily
- RING-type zinc-finger
- Ring finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- ubiquitin-protein transferase activity
- B-box zinc finger
- Outer membrane protein (OmpH-like)
- Apolipoprotein A1/A4/E domain
- SPRY-associated domain
- Zinc finger, C3HC4 type (RING finger)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial neoplasia
- epithelial cancer
- cancer
- liver neoplasia
- liver cancer
- digestive system cancer
- abdominal cancer
- lung adenocarcinoma formation
- breast adenocarcinoma
regulates
- NFkB (complex)
- CARD9
role in cell
- replication in
- proliferation
- invasion by
- migration
- penetration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Trim62 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of epithelial to mesenchymal transition
- release of virus from host
- regulation of viral entry into host cell
- positive regulation of transcription, DNA-dependent
- innate immune response
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- positive regulation of sequence-specific DNA binding transcription factor activity
- positive regulation of NF-kappaB transcription factor activity
- protein K27-linked ubiquitination
- negative regulation of viral transcription
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- identical protein binding
- zinc ion binding
- protein binding
- transcription coactivator activity