TRIM62 Gene Summary [Human]
Enables identical protein binding activity; transcription coactivator activity; and ubiquitin-protein transferase activity. Involved in several processes, including negative regulation of viral transcription; positive regulation of NF-kappaB transcription factor activity; and positive regulation of antifungal innate immune response. Is active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | TRIM62 |
| Official Name | tripartite motif containing 62 [Source:HGNC Symbol;Acc:HGNC:25574] |
| Ensembl ID | ENSG00000116525 |
| Bio databases IDs | |
| Aliases | tripartite motif containing 62, ductal epithelium-associated RING Chromosome 1 |
| Synonyms | 6330414G21Rik, DEAR1, tripartite motif-containing 62 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TRIM62 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Cortexillin I, coiled coil
- coiled-coil (CC) domain of Drosophila brain tumor (brat) and similar proteins
- transcription co-activator
- B-Box C-terminal domain
- SPRY domain
- zinc finger of C3HC4-type, RING
- ubiquitin protein ligase activity
- Uso1 / p115 like vesicle tethering protein, C terminal region
- enzyme
- Ring finger domain
- protein binding
- identical protein binding
- associated with SPRY domains
- ZW10 interactor
- B-box-type zinc finger superfamily
- RING-type zinc-finger
- Ring finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- ubiquitin-protein transferase activity
- B-box zinc finger
- Outer membrane protein (OmpH-like)
- Apolipoprotein A1/A4/E domain
- SPRY-associated domain
- Zinc finger, C3HC4 type (RING finger)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial neoplasia
- epithelial cancer
- cancer
- liver neoplasia
- liver cancer
- digestive system cancer
- abdominal cancer
- lung adenocarcinoma formation
- breast adenocarcinoma
regulates
- NFkB (complex)
- CARD9
role in cell
- replication in
- proliferation
- invasion by
- migration
- penetration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TRIM62 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of epithelial to mesenchymal transition
- release of virus from host
- regulation of viral entry into host cell
- positive regulation of transcription, DNA-dependent
- innate immune response
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- positive regulation of sequence-specific DNA binding transcription factor activity
- positive regulation of NF-kappaB transcription factor activity
- protein K27-linked ubiquitination
- negative regulation of viral transcription
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- identical protein binding
- zinc ion binding
- protein binding
- transcription coactivator activity