Card9 Gene Summary [Mouse]
Enables CARD domain binding activity. Involved in several processes, including antifungal innate immune response; positive regulation of MAPK cascade; and regulation of gene expression. Acts upstream of or within several processes, including positive regulation of JNK cascade; regulation of cytokine production; and response to bacterium. Part of CBM complex. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human CARD9 (caspase recruitment domain family member 9). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Card9 |
| Official Name | caspase recruitment domain family, member 9 [Source:MGI Symbol;Acc:MGI:2685628] |
| Ensembl ID | ENSMUSG00000026928 |
| Bio databases IDs | |
| Aliases | caspase recruitment domain family, member 9 |
| Synonyms | CANDF2, caspase recruitment domain family member 9, caspase recruitment domain family, member 9, Gm782, hCARD9, IMD103, LOC64171 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Card9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CARD domain binding
- Caspase recruitment domain
- protein binding activity, bridging
- protein homodimerization
- protein binding
- identical protein binding
- Death Domain Superfamily of protein-protein interaction domains
Pathways
Biological processes and signaling networks where the Card9 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetes mellitus
- ulcerative colitis
- Crohn disease
- infection
- IgA nephropathy
- familial candidiasis type 2
- atherosclerosis
- inflammatory bowel disease
- cognitive impairment
- lipopolysaccharide-induced sepsis
role in cell
- activation in
- expression in
- activation
- proliferation
- phosphorylation in
- inhibition in
- apoptosis
- recruitment
- differentiation
- accumulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- cytoplasmic particles
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Card9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to peptidoglycan
- response to muramyl dipeptide
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- JNK cascade
- response to xenobiotic stimulus
- positive regulation of NF-kappaB transcription factor activity
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of macrophage cytokine production
- positive regulation of T-helper 17 type immune response
- positive regulation of granulocyte macrophage colony-stimulating factor production
- response to exogenous dsRNA
- positive regulation of interleukin-17 production
- regulation of interleukin-2 production
- defense response to virus
- positive regulation of tumor necrosis factor production
- positive regulation of chemokine production
- defense response to Gram-positive bacterium
- stress-activated MAPK cascade
- protein homooligomerization
- regulation of apoptotic process
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
- neutrophil mediated immunity
- homeostasis of number of cells in a free-living population
- positive regulation of innate immune response
- positive regulation of JNK cascade
- immunoglobulin mediated immune response
- positive regulation of ERK1 and ERK2 cascade
- positive regulation of interleukin-6 production
- positive regulation of cytokine production
- positive regulation of stress-activated MAPK cascade
Cellular Component
Where in the cell the gene product is active
- CBM complex
- cytoplasm
- cytosol
- macromolecular complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein homodimerization activity
- protein binding
- signaling adaptor activity
- metal ion binding
- CARD domain binding