Tssk1 Gene Summary [Mouse]
Enables magnesium ion binding activity and protein serine/threonine kinase activity. Involved in peptidyl-serine phosphorylation and spermatid development. Located in motile cilium. Is expressed in embryo; seminiferous tubule; spermatid; and testis. Orthologous to several human genes including TSSK1B (testis specific serine kinase 1B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tssk1 |
| Official Name | testis-specific serine kinase 1 [Source:MGI Symbol;Acc:MGI:1347557] |
| Ensembl ID | ENSMUSG00000041566 |
| Bio databases IDs | |
| Aliases | testis-specific serine kinase 1 |
| Synonyms | FKSG81, SPOGA4, Stk22a, STK22D, testis-specific serine kinase 1, testis-specific serine kinase 1B, TSK-1, Tssk, TSSK1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tssk1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- Protein tyrosine and serine/threonine kinase
- ATP binding
- protein binding
- magnesium ion binding
- Protein kinase domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- binding protein
- Protein Kinases, catalytic domain
- Tyrosine kinase, catalytic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- motile cilia
- acrosome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tssk1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- spermatid development
- protein phosphorylation
Cellular Component
Where in the cell the gene product is active
- motile cilium
- acrosomal vesicle
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- ATP binding
- protein binding
- protein serine/threonine kinase activity