Foxn4 Gene Summary [Mouse]
Enables DNA-binding transcription factor activity, RNA polymerase II-specific; chromatin binding activity; and cis-regulatory region sequence-specific DNA binding activity. Involved in neural retina development; positive regulation of transcription by RNA polymerase II; and ventral spinal cord interneuron fate commitment. Acts upstream of or within neuron fate commitment. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; eye; metanephros; and respiratory system. Orthologous to human FOXN4 (forkhead box N4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Foxn4 |
| Official Name | forkhead box N4 [Source:MGI Symbol;Acc:MGI:2151057] |
| Ensembl ID | ENSMUSG00000042002 |
| Bio databases IDs | |
| Aliases | forkhead box N4 |
| Synonyms | forkhead box N4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Foxn4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- FH_FOX
- double-stranded DNA binding
- nucleic acid binding
- chromatin binding
- protein binding
- sequence-specific DNA binding
- Forkhead domain
- FORKHEAD
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insomnia
- preeclampsia
- hypoplasia
role in cell
- number
- differentiation
- quantity
- abnormal morphology
- lack
- commitment
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Foxn4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- amacrine cell differentiation
- retina layer formation
- regulation of heart contraction
- regulation of transcription, DNA-dependent
- heart looping
- ventral spinal cord interneuron differentiation
- positive regulation of transcription from RNA polymerase II promoter
- ventral spinal cord interneuron fate commitment
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- protein binding
- core promoter proximal region sequence-specific DNA binding
- chromatin binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity