Rfx2 Gene Summary [Mouse]
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in acrosome assembly; cilium assembly; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; liver; ovary; primitive streak; and sensory organ. Orthologous to human RFX2 (regulatory factor X2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rfx2 |
| Official Name | regulatory factor X, 2 (influences HLA class II expression) [Source:MGI Symbol;Acc:MGI:106583] |
| Ensembl ID | ENSMUSG00000024206 |
| Bio databases IDs | |
| Aliases | regulatory factor X, 2 (influences HLA class II expression) |
| Synonyms | 5430432H19RIK, regulatory factor X2, regulatory factor X, 2 (influences HLA class II expression) |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rfx2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- RFX DNA-binding domain
- transcription regulator
- nucleic acid binding
- double-stranded DNA binding
- RFX1 transcription activation region
- protein binding
- sequence-specific DNA binding
- transcription factor activity
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- growth failure
- schizophrenia
- azoospermia
- cervical cancer
role in cell
- expression in
- apoptosis
- formation
- assembly
- abnormal morphology
- development
- arrangement
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rfx2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- acrosome assembly
- cilium morphogenesis
- spermatid development
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- chromatin
Molecular Function
What the gene product does at the molecular level
- DNA binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity