FOXN4 Gene Summary [Human]
Members of the winged-helix/forkhead family of transcription factors, such as FOXN4, are characterized by a 110-amino acid DNA-binding domain that can fold into a variant of the helix-turn-helix motif consisting of 3 alpha helices flanked by 2 large loops or wings. These transcription factors are involved in a variety of biologic processes as key regulators in development and metabolism (Li et al., 2004 [PubMed 15363391]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | FOXN4 |
| Official Name | forkhead box N4 [Source:HGNC Symbol;Acc:HGNC:21399] |
| Ensembl ID | ENSG00000139445 |
| Bio databases IDs | |
| Aliases | forkhead box N4 |
| Synonyms | forkhead box N4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FOXN4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- FH_FOX
- double-stranded DNA binding
- nucleic acid binding
- chromatin binding
- protein binding
- sequence-specific DNA binding
- Forkhead domain
- FORKHEAD
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insomnia
- preeclampsia
- hypoplasia
role in cell
- number
- differentiation
- quantity
- abnormal morphology
- lack
- commitment
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FOXN4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- amacrine cell differentiation
- retina layer formation
- regulation of heart contraction
- regulation of transcription, DNA-dependent
- heart looping
- ventral spinal cord interneuron differentiation
- positive regulation of transcription from RNA polymerase II promoter
- ventral spinal cord interneuron fate commitment
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- protein binding
- core promoter proximal region sequence-specific DNA binding
- chromatin binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity