Bend6 Gene Summary [Mouse]
Enables chromatin binding activity and transcription corepressor activity. Acts upstream of or within negative regulation of Notch signaling pathway and positive regulation of neuron differentiation. Located in nucleus. Is expressed in telencephalon. Orthologous to human BEND6 (BEN domain containing 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bend6 |
| Official Name | BEN domain containing 6 [Source:MGI Symbol;Acc:MGI:2444572] |
| Ensembl ID | ENSMUSG00000042182 |
| Bio databases IDs | |
| Aliases | BEN domain containing 6 |
| Synonyms | B230209C24Rik, BEN domain containing 6, C6orf65, RGD1310392 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Bend6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- The BEN domain is found in diverse animal proteins
- transcription co-repressor
- chromatin binding
- BEN domain
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Bend6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription, DNA-dependent
- nervous system development
- positive regulation of neuron differentiation
- negative regulation of Notch signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
Molecular Function
What the gene product does at the molecular level
- DNA binding
- transcription corepressor activity
- chromatin binding