LTO1 Gene Summary [Mouse]
Predicted to be involved in gene expression; ribosomal large subunit biogenesis; and telomere maintenance. Predicted to be located in nucleus. Is expressed in cerebellum and rest of cerebellum mantle layer. Orthologous to human LTO1 (LTO1 maturation factor of ABCE1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | LTO1 |
| Official Name | ABCE maturation factor [Source:MGI Symbol;Acc:MGI:1919534] |
| Ensembl ID | ENSMUSG00000031072 |
| Bio databases IDs | |
| Aliases | ABCE maturation factor |
| Synonyms | 2210010N10Rik, ABCE maturation factor, CIAB1, LOC100503188, LTO1 maturation factor of ABCE1, ORAOV1, TAOS1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lto1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Essential protein Yae1, N terminal
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- oral squamous cell carcinoma
- squamous cell cancer of the oral cavity
- head and neck squamous cell carcinoma
- head and neck squamous cell cancer
- gout
regulates
- ribosomal large subunit
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lto1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ribosomal large subunit biogenesis
- telomere maintenance
- translational initiation
Cellular Component
Where in the cell the gene product is active
- nucleus
Molecular Function
What the gene product does at the molecular level
- protein binding