Dmtf1 Gene Summary [Mouse]
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; limb; and retina. Orthologous to human DMTF1 (cyclin D binding myb like transcription factor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dmtf1 |
| Official Name | cyclin D binding myb-like transcription factor 1 [Source:MGI Symbol;Acc:MGI:1344415] |
| Ensembl ID | ENSMUSG00000042508 |
| Bio databases IDs | |
| Aliases | cyclin D binding myb-like transcription factor 1 |
| Synonyms | cyclin D binding myb-like transcription factor 1, Dimp, DMP1, DMTF, hDMP1, MRUL |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dmtf1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SANT
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
- Cyclin-D-binding Myb-like transcription factor 1 N-terminal
- DNA binding domain
- nucleic acid binding
- double-stranded DNA binding
- Myb-like DNA-binding domain
- sequence-specific DNA binding
- acidic domain
- Myb repeat
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- tumorigenesis
- neoplasia
- schizophrenia
- mammary neoplasm
- major depression
- seizures
- idiopathic dilated cardiomyopathy
- growth failure
- cancer
- B-cell non-Hodgkin disease
role in cell
- expression in
- activation in
- accumulation in
- growth
- cell death
- number
- differentiation
- proliferation
- cell cycle progression
- transformation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dmtf1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of transcription, DNA-dependent
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity