DMTF1 Gene Summary [Human]
This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
Details
| Type | Protein Coding |
| Official Symbol | DMTF1 |
| Official Name | cyclin D binding myb like transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:14603] |
| Ensembl ID | ENSG00000135164 |
| Bio databases IDs | |
| Aliases | cyclin D binding myb like transcription factor 1, cyclin D-binding Myb-like protein |
| Synonyms | cyclin D binding myb-like transcription factor 1, Dimp, DMP1, DMTF, hDMP1, MRUL |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DMTF1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SANT
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
- Cyclin-D-binding Myb-like transcription factor 1 N-terminal
- DNA binding domain
- nucleic acid binding
- double-stranded DNA binding
- Myb-like DNA-binding domain
- sequence-specific DNA binding
- acidic domain
- Myb repeat
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- tumorigenesis
- neoplasia
- schizophrenia
- mammary neoplasm
- major depression
- seizures
- idiopathic dilated cardiomyopathy
- growth failure
- cancer
- B-cell non-Hodgkin disease
role in cell
- expression in
- activation in
- accumulation in
- growth
- cell death
- number
- differentiation
- proliferation
- cell cycle progression
- transformation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DMTF1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of transcription, DNA-dependent
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity