Asb4 Gene Summary [Mouse]
Enables ubiquitin protein ligase activity and ubiquitin protein ligase binding activity. Involved in positive regulation of vasculogenesis and protein autoubiquitination. Part of Cul2-RING ubiquitin ligase complex and Cul5-RING ubiquitin ligase complex. Is expressed in several structures, including brain; cardiovascular system; extraembryonic component; genitourinary system; and limb. Used to study pre-eclampsia. Orthologous to human ASB4 (ankyrin repeat and SOCS box containing 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Asb4 |
| Official Name | ankyrin repeat and SOCS box-containing 4 [Source:MGI Symbol;Acc:MGI:1929751] |
| Ensembl ID | ENSMUSG00000042607 |
| Bio databases IDs | |
| Aliases | ankyrin repeat and SOCS box-containing 4 |
| Synonyms | 8430401O13Rik, ankyrin repeat and SOCS box-containing 4, FLJ39130, LOC285986 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Asb4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SOCS box
- ubiquitin protein ligase binding
- transcription regulator
- Ankyrin repeats (many copies)
- ubiquitin protein ligase activity
- ubiquitin-protein transferase activity
- Ankyrin repeats (3 copies)
- enzyme binding
- SOCS
- protein binding
- Ankyrin repeat
- ankyrin repeats
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- albuminuria
- prostate cancer
- hypertension
- irritable bowel syndrome
- prolonged pregnancy
- weight gain
- glomerular endotheliosis
- severe acute respiratory syndrome
- obesity
- progression free survival
role in cell
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Asb4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of vasculogenesis
- intracellular signal transduction
- protein autoubiquitination
Cellular Component
Where in the cell the gene product is active
- cytosol
- Cul2-RING ubiquitin ligase complex
- Cul5-RING ubiquitin ligase complex
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- ubiquitin protein ligase binding