Tubb3 Gene Summary [Mouse]
Enables netrin receptor binding activity. Involved in axon guidance and netrin-activated signaling pathway. Located in several cellular components, including filopodium; growth cone; and lamellipodium. Is expressed in several structures, including alimentary system; cardiovascular system; integumental system; nervous system; and sensory organ. Used to study congenital fibrosis of the extraocular muscles. Human ortholog(s) of this gene implicated in complex cortical dysplasia with other brain malformations 1 and congenital fibrosis of the extraocular muscles 3A. Orthologous to human TUBB3 (tubulin beta 3 class III). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tubb3 |
| Official Name | tubulin, beta 3 class III [Source:MGI Symbol;Acc:MGI:107813] |
| Ensembl ID | ENSMUSG00000062380 |
| Bio databases IDs | |
| Aliases | tubulin, beta 3 class III |
| Synonyms | 3200002H15Rik, beta-4, CDCBM, CDCBM1, CFEOM3, CFEOM3A, FEOM3, M(beta)3, M(beta)6, MC1R, M(β)3, M(β)6, Nst, Tbb3, TUBB4, Tub beta3, Tubulin beta-3, tubulin beta 3 class III, tubulin, beta 3 class III, Tubulin beta-III, Tubulin β-3, tubulin β 3 class III, tubulin, β 3 class III, Tubulin β-III, TUJ1, β-4, β iii tubulin, β tubulin iii |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tubb3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GTP binding
- Tubulin protein family of FtsZ and CetZ-like
- peptide binding
- Tubulin C-terminal domain
- structural constituent of cytoskeleton
- Tubulin/FtsZ family, GTPase domain
- protein binding
- receptor binding
- Tubulin/FtsZ family, C-terminal domain
Pathways
Biological processes and signaling networks where the Tubb3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- relapsed acute lymphocytic leukemia
- acute myeloid leukemia
- acute lymphoblastic lymphoma
- ovarian neoplasm
- epithelial cancer
- cancer
- non-small cell lung carcinoma
- metastatic breast cancer
- HER2-positive breast cancer
role in cell
- expression in
- quantity
- apoptosis
- cell viability
- migration
- survival
- proliferation
- growth
- cell death
- accumulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubule cytoskeleton
- cell periphery
- intracellular space
- Nucleus
- microtubules
- cytoplasmic bridges
- proximal nerve stump
- growth cone
- neurites
- filopodia
- mitotic spindle
- perikaryon
- axons
- dendrites
- lamellipodia
- sensory axons
- sympathetic axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tubb3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- axon guidance
- microtubule cytoskeleton organization
- netrin-activated signaling pathway
- mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- microtubule cytoskeleton
- neuronal cell body
- microtubule
- growth cone
- dendrite
- nucleus
- intercellular bridge
- extracellular vesicular exosome
- mitotic spindle
- cytoplasm
- filopodium
- axon
- lamellipodium
- cell periphery
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- metal ion binding
- GTPase activity
- peptide binding
- structural constituent of cytoskeleton