Gpr149 Gene Summary [Mouse]

Predicted to enable G protein-coupled receptor activity and neuropeptide binding activity. Acts upstream of or within antral ovarian follicle growth; negative regulation of ovulation; and preantral ovarian follicle growth. Predicted to be active in neuron projection and plasma membrane. Orthologous to human GPR149 (G protein-coupled receptor 149). [provided by Alliance of Genome Resources, Apr 2025]

Details

Type
Protein Coding
Official Symbol
Gpr149
Official Name
G protein-coupled receptor 149 [Source:MGI Symbol;Acc:MGI:2443628]
Ensembl ID
ENSMUSG00000043441
Bio databases IDs NCBI: 229357 Ensembl: ENSMUSG00000043441
Aliases G protein-coupled receptor 149
Synonyms 9630018L10RIK, G protein-coupled receptor 149, IEDA, PGR10, R35
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gpr149 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • G-protein coupled receptor
  • seven-transmembrane G protein-coupled receptor superfamily

Pathways

Biological processes and signaling networks where the Gpr149 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
disease
  • cancer
  • cardiovascular disorder
  • coronary artery disease
  • myocardial infarction
regulated by

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Plasma Membrane
  • cellular membrane

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Gpr149 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • neuropeptide signaling pathway
  • preantral ovarian follicle growth
  • antral ovarian follicle growth
  • negative regulation of ovulation

Cellular Component

Where in the cell the gene product is active
  • neuron projection
  • plasma membrane

Molecular Function

What the gene product does at the molecular level
  • G-protein coupled receptor activity
  • neuropeptide binding

Gene-Specific Assays for Results You Can Trust

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