Clrn1 Gene Summary [Mouse]
Acts upstream of or within auditory receptor cell stereocilium organization; neuromuscular process controlling balance; and sensory perception of sound. Located in several cellular components, including basal part of cell; stereocilium; and trans-Golgi network transport vesicle. Is expressed in gut; male reproductive gland or organ; nervous system; sensory organ; and skin. Used to study Usher syndrome type 3 and Usher syndrome type 3A. Human ortholog(s) of this gene implicated in Usher syndrome type 3A and retinitis pigmentosa 61. Orthologous to human CLRN1 (clarin 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Clrn1 |
| Official Name | clarin 1 [Source:MGI Symbol;Acc:MGI:2388124] |
| Ensembl ID | ENSMUSG00000043850 |
| Bio databases IDs | |
| Aliases | clarin 1 |
| Synonyms | A130002D11Rik, clarin-1, RP61, USH3, USH3A |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Clrn1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Usher syndrome type 3A
- retinitis pigmentosa type 61
- Usher syndrome type 3
- retinal dystrophy
- Usher syndrome
- retinitis pigmentosa
- hearing loss
role in cell
- motility
- formation
- assembly
- organization
- maintenance
- disorganization
- function
- orientation
- lack
- reorganization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- microtubule cytoskeleton
- basal compartment
- cellular membrane
- Golgi Apparatus
- stereocilia
- cellular protrusions
- microvilli
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Clrn1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell motility
- sensory perception of sound
- auditory receptor cell stereocilium organization
- positive regulation of lamellipodium assembly
- photoreceptor cell maintenance
- equilibrioception
- actin filament organization
- sensory perception of light stimulus
- visual perception
Cellular Component
Where in the cell the gene product is active
- microtubule cytoskeleton
- basal part of cell
- microvillus
- trans-Golgi network transport vesicle
- stereocilium
- plasma membrane
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- protein binding