Slc34a3 Gene Summary [Mouse]
Enables sodium:phosphate symporter activity. Acts upstream of or within phosphate ion transport. Located in apical plasma membrane and brush border membrane. Is expressed in several structures, including extraembryonic component; genitourinary system; and small intestine. Human ortholog(s) of this gene implicated in hereditary hypophosphatemic rickets with hypercalciuria. Orthologous to human SLC34A3 (solute carrier family 34 member 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc34a3 |
| Official Name | solute carrier family 34 (sodium phosphate), member 3 [Source:MGI Symbol;Acc:MGI:2159410] |
| Ensembl ID | ENSMUSG00000006469 |
| Bio databases IDs | |
| Aliases | solute carrier family 34 (sodium phosphate), member 3 |
| Synonyms | HHRH, LOC246234, naPi-2c, NPT2C, Npt2c-v1, NPTIIc, Sodium Phosphate Cotransporter Type2c, solute carrier family 34 member 3, solute carrier family 34 (sodium phosphate), member 3, Type ii sodium phosphate cotransporter |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slc34a3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Phosphate:Na+ Symporter (PNaS) Family
- protein binding
- sodium:phosphate symporter
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- autosomal recessive hypophosphatemic rickets with hypercalciuria
- hypercalcemia
- renal phosphate wasting
- hypophosphatemic nephrolithiasis/osteoporosis type 1
- hypercalciuria
regulates
- adenosine triphosphate
- Ca2+
- Na+
- FGF23
- phosphate
- calcitriol
- vitamin D
role in cell
- homeostasis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- apical membrane
- brush border
- brush border membrane vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Slc34a3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sodium ion transport
- phosphate ion transport
- sodium-dependent phosphate transport
- sodium ion transmembrane transport
- cellular phosphate ion homeostasis
Cellular Component
Where in the cell the gene product is active
- brush border membrane
- brush border
- vesicle
- plasma membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- sodium:phosphate symporter activity
- protein binding