Hamp Gene Summary [Mouse]
This gene encodes hepcidin, an antimicrobial peptide and master hormonal regulator of systemic iron metabolism. The encoded preproprotein is synthesized in the hepatocytes where it undergoes proteolytic processing to generate disulfide-linked mature peptides that are secreted into the bloodstream. Mice lacking the encoded protein develop multivisceral iron overlaod, with sparing of the spleen macrophages. Certain mutations in the human ortholog of this gene cause hemochromatosis type 2B, also known as juvenile hemochromatosis. This gene is located adjacent to a related hepcidin gene on chromosome 7. [provided by RefSeq, Aug 2016]
Details
| Type | Protein Coding |
| Official Symbol | Hamp |
| Official Name | hepcidin antimicrobial peptide [Source:MGI Symbol;Acc:MGI:1933533] |
| Ensembl ID | ENSMUSG00000050440 |
| Bio databases IDs | |
| Aliases | hepcidin antimicrobial peptide |
| Synonyms | Hamp1, HEPC, Hepc1, HEPCIDIN, hepcidin antimicrobial peptide, HFE2B, LEAP1, PLTR |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hamp often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- copper ion binding
- Hepcidin
- hormone
- receptor binding
Pathways
Biological processes and signaling networks where the Hamp gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- memory deficits
- liver cancer
- type 2B hemochromatosis
- rheumatoid arthritis
- anisocytosis
- gestational diabetes mellitus
- juvenile hemochromatosis
- hepatocellular carcinoma
- hepatitis B virus-related hepatocellular carcinoma
role in cell
- expression in
- activation
- proliferation
- cellular infiltration by
- abnormal morphology
- organismal death
- homeostasis
- binding in
- homeostasis in
- degradation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Nucleus
- intercellular junctions
- apical cortex
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hamp gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- multicellular organismal iron ion homeostasis
- negative regulation of iron ion transmembrane transport
- negative regulation of inflammatory response
- protein catabolic process
- transcription from RNA polymerase II promoter
- positive regulation of protein catabolic process
- myeloid cell homeostasis
- positive regulation of transcription from RNA polymerase II promoter
- negative regulation of bone resorption
- defense response to bacterium
- macrophage activation
- JAK-STAT cascade
- cellular iron ion homeostasis
- negative regulation of transcription from RNA polymerase II promoter
- inflammatory response
- immune response
- positive regulation of macrophage activation
- killing of cells of other organism
- response to iron ion
- establishment of localization in cell
- defense response to fungus
- iron ion transmembrane transport
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular space
- extracellular region
Molecular Function
What the gene product does at the molecular level
- copper ion binding
- hormone activity