Oxgr1 Gene Summary [Mouse]
Predicted to enable AMP binding activity; G protein-coupled adenosine receptor activity; and purine nucleoside binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to act upstream of or within adenylate cyclase-modulating G protein-coupled receptor signaling pathway. Predicted to be active in plasma membrane. Is expressed in epididymis; metanephros; neural retina; and retina. Human ortholog(s) of this gene implicated in calcium oxalate nephrolithiasis. Orthologous to human OXGR1 (oxoglutarate receptor 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Oxgr1 |
| Official Name | oxoglutarate (alpha-ketoglutarate) receptor 1 [Source:MGI Symbol;Acc:MGI:2685145] |
| Ensembl ID | ENSMUSG00000044819 |
| Bio databases IDs | |
| Aliases | oxoglutarate (alpha-ketoglutarate) receptor 1 |
| Synonyms | aKGR, CAON2, Cysltr3, Gm299, GPR80, GPR99, oxoglutarate (alpha-ketoglutarate) receptor 1, oxoglutarate receptor 1, oxoglutarate (α-ketoglutarate) receptor 1, P2RY15, P2Y15 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Oxgr1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Cholecystokinin A receptor, N-terminal
- AMP binding
- G-protein coupled adenosine receptor
- binding protein
- 7 transmembrane receptor (rhodopsin family)
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the Oxgr1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- DDX24
- leukotriene E4
disease
- calcium oxalate nephrolithiasis type 2 without nephrocalcinosis
- calcium oxalate nephrolithiasis type 2 with or without nephrocalcinosis
- androgenic alopecia
- calcium oxalate nephrolithiasis type 2 with nephrocalcinosis
- vascular leak syndrome
- Huntington disease
regulated by
- 2-oxoglutaric acid
- TCOF1
role in cell
- signaling in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- microsomal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Oxgr1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- signaling receptor activity