Prlhr Gene Summary [Mouse]
Enables G protein-coupled receptor activity. Acts upstream of or within G protein-coupled receptor signaling pathway; feeding behavior; and hormone metabolic process. Is active in cilium. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human PRLHR (prolactin releasing hormone receptor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Prlhr |
| Official Name | prolactin releasing hormone receptor [Source:MGI Symbol;Acc:MGI:2135956] |
| Ensembl ID | ENSMUSG00000045052 |
| Bio databases IDs | |
| Aliases | prolactin releasing hormone receptor |
| Synonyms | Gm339, GPR10, GR3, prolactin releasing hormone receptor, PrRPR, PrRP receptor, Uhr-1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Prlhr often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- neuropeptide receptor
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
- polypeptide hormone binding
Pathways
Biological processes and signaling networks where the Prlhr gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- weight gain
- Huntington disease
- diarrhea
- withdrawal syndrome
- obesity
- adult-onset obesity
regulated by
- forskolin
- bromocriptine
- CREB
role in cell
- proliferation
- phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- cilia
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Prlhr gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuropeptide signaling pathway
- G-protein coupled receptor signaling pathway
- feeding behavior
- female pregnancy
- hormone metabolic process
Cellular Component
Where in the cell the gene product is active
- cilium
- neuron projection
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- neuropeptide binding
- protein binding
- neuropeptide receptor activity
- neuropeptide Y receptor activity