Fam83h Gene Summary [Mouse]
Predicted to enable keratin filament binding activity and protein kinase binding activity. Predicted to be involved in several processes, including intermediate filament cytoskeleton organization; positive regulation of cell migration; and protein localization to cytoskeleton. Predicted to be located in cytoplasm. Predicted to colocalize with keratin filament. Is expressed in lower jaw and tooth. Human ortholog(s) of this gene implicated in amelogenesis imperfecta type 3A. Orthologous to human FAM83H (family with sequence similarity 83 member H). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fam83h |
| Official Name | family with sequence similarity 83, member H [Source:MGI Symbol;Acc:MGI:2145900] |
| Ensembl ID | ENSMUSG00000046761 |
| Bio databases IDs | |
| Aliases | family with sequence similarity 83, member H |
| Synonyms | AI3, AI3A, family with sequence similarity 83 member H, family with sequence similarity 83, member H, FLJ46072, RGD1305866 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fam83h often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- intermediate filament binding
- protein kinase binding
- FAM83 A-H
- PLD-like domain
- protein binding
- Catalytic domain of phospholipase D superfamily proteins
- Spt5 C-terminal nonapeptide repeat binding Spt4
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- keratin intermediate filaments
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fam83h gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein localization to cytoskeleton
- signal transduction
- intermediate filament cytoskeleton organization
- biomineral tissue development
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- keratin filament
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding