Kif14 Gene Summary [Mouse]
Enables several functions, including ATP binding activity; ATP hydrolysis activity; and plus-end-directed microtubule motor activity. Involved in several processes, including brain development; negative regulation of neuron apoptotic process; and regulation of myelination. Predicted to be located in several cellular components, including Flemming body; cytosol; and spindle midzone. Predicted to be part of kinesin complex. Predicted to be active in cytoplasm and microtubule. Predicted to colocalize with plasma membrane. Is expressed in heart and retina. Human ortholog(s) of this gene implicated in Meckel syndrome and primary autosomal recessive microcephaly 20. Orthologous to human KIF14 (kinesin family member 14). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Kif14 |
| Official Name | kinesin family member 14 [Source:MGI Symbol;Acc:MGI:1098226] |
| Ensembl ID | ENSMUSG00000041498 |
| Bio databases IDs | |
| Aliases | kinesin family member 14 |
| Synonyms | D1Ertd367e, E130203M01, KIAA0042, KIF14F, kinesin family member 14, MCPH20, MKS12 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Kif14 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Arginine and glutamate-rich 1
- protein kinase binding
- Ezrin/radixin/moesin, alpha-helical domain
- Myosin and Kinesin motor domain
- ATP binding
- Forkhead associated domain
- enzyme
- protein binding
- motor domain
- ATPase
- PDZ-domain binding
- Kinesin-associated
- forkhead associated (FHA) domain superfamily
- Kinesin motor, catalytic domain
- microtubule binding
- prefoldin
- FHA domain
- tubulin binding
- stalk region
- Kinesin motor domain
- tail domain
- plus-end-directed kinesin ATPase
- Domain of unknown function (DUF4200)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- invasive breast cancer
- autosomal recessive primary microcephaly type 20
- invasive breast carcinoma
- lung squamous cell carcinoma
- squamous cell lung cancer
- mammary neoplasm
- non-small cell lung cancer
- prostate cancer
regulates
- proteasome
- CIT
role in cell
- adhesion
- proliferation
- apoptosis
- growth
- migration
- misalignment
- myelination
- multinucleation
- chromosomal congression
- misalignment in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Nucleus
- Plasma Membrane
- microtubules
- contractile rings
- midbody
- Flemming body
- cytosol
- spindle pole
- central spindle
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Kif14 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of cell proliferation
- microtubule-based movement
- regulation of neuron apoptotic process
- microtubule depolymerization
- cerebellar cortex development
- olfactory bulb development
- negative regulation of neuron apoptotic process
- cell division
- substrate adhesion-dependent cell spreading
- regulation of Rap protein signal transduction
- activation of protein kinase activity
- positive regulation of cytokinesis
- cell proliferation in forebrain
- hippocampus development
- cerebral cortex development
- cerebellar granular layer structural organization
- establishment of protein localization
- proteasomal ubiquitin-dependent protein catabolic process
- cerebellar Purkinje cell layer structural organization
- regulation of cell growth
- negative regulation of apoptotic process
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
- regulation of myelination
- regulation of G1/S transition of mitotic cell cycle
- regulation of cell adhesion
- regulation of cell migration
- negative regulation of integrin activation
- mitotic metaphase plate congression
- regulation of G2/M transition of mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- nucleus
- spindle midzone
- membrane
- cytosol
- kinesin complex
- midbody
- plasma membrane
- microtubule
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- protein kinase binding
- tubulin binding
- ATP binding
- microtubule motor activity
- protein binding
- PDZ domain binding
- plus-end-directed microtubule motor activity
- microtubule binding