Tefm Gene Summary [Mouse]
Predicted to enable DNA polymerase processivity factor activity and transcription elongation factor activity. Predicted to be involved in mitochondrial transcription; oxidative phosphorylation; and positive regulation of mitochondrial transcription. Predicted to be located in mitochondrial matrix. Predicted to be part of ribonucleoprotein complex. Predicted to be active in mitochondrial nucleoid. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency. Orthologous to human TEFM (transcription elongation factor, mitochondrial). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tefm |
| Official Name | transcription elongation factor, mitochondrial [Source:MGI Symbol;Acc:MGI:1915800] |
| Ensembl ID | ENSMUSG00000046909 |
| Bio databases IDs | |
| Aliases | transcription elongation factor, mitochondrial |
| Synonyms | 1110002N22Rik, C17orf42, COXPD58, RGD1306595, transcription elongation factor, mitochondrial |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tefm often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Crossover junction endodeoxyribonuclease RuvC and similar proteins
- transcription regulator
- DNA polymerase processivity factor
- protein binding
- Helix-hairpin-helix motif
- transcriptional elongation regulator
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial matrix
- mitochondrial nucleoids
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tefm gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transcription from mitochondrial promoter
- oxidative phosphorylation
- transcription elongation from mitochondrial promoter
- mitochondrial DNA replication
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- mitochondrion
- mitochondrial nucleoid
Molecular Function
What the gene product does at the molecular level
- DNA polymerase processivity factor activity
- RNA binding
- protein binding
- crossover junction endodeoxyribonuclease activity