Bola2 Gene Summary [Mouse]
Predicted to enable iron-sulfur cluster binding activity. Predicted to be involved in [2Fe-2S] cluster assembly; intracellular iron ion homeostasis; and protein maturation. Predicted to be located in cytoplasm. Predicted to be part of iron-sulfur cluster assembly complex. Predicted to be active in cytosol and nucleus. Orthologous to several human genes including BOLA2 (bolA family member 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Retained Intron |
| Official Symbol | Bola2 |
| Official Name | bolA-like 2 (E. coli) [Source:MGI Symbol;Acc:MGI:1913412] |
| Ensembl ID | ENSMUSG00000047721 |
| Bio databases IDs | |
| Aliases | bolA-like 2 (E. coli) |
| Synonyms | 1110025L05Rik, BOLA2, bolA family member 2, bolA family member 2B, LOC101060252, LOC102725214, RGD1565363 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Bola2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- BolA-like protein
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Bola2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular iron ion homeostasis
- [2Fe-2S] cluster assembly
- cell redox homeostasis
- iron-sulfur cluster assembly
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- iron-sulfur cluster binding
- 2 iron, 2 sulfur cluster binding