Glrx3 Gene Summary [Mouse]
Predicted to enable identical protein binding activity and protein kinase C binding activity. Involved in negative regulation of cardiac muscle hypertrophy and regulation of the force of heart contraction. Located in Z disc. Is expressed in several structures, including brain; egg cylinder; genitourinary system; gut; and white fat. Orthologous to human GLRX3 (glutaredoxin 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Glrx3 |
| Official Name | glutaredoxin 3 [Source:MGI Symbol;Acc:MGI:1353653] |
| Ensembl ID | ENSMUSG00000031068 |
| Bio databases IDs | |
| Aliases | glutaredoxin 3 |
| Synonyms | GLRX4, glutaredoxin 3, GRX3, GRX4, PICOT, TXNL2, TXNL3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Glrx3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- thioredoxin-like domain
- protein kinase C binding
- Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
- enzyme
- protein binding
- identical protein binding
- thioredoxin
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colon cancer
role in cell
- phosphorylation in
- binding in
- interaction in
- hypertrophy
- transactivation in
- homeostasis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent resistant lipid raft fraction
- cilia
- cell periphery
- Plasma Membrane
- microtubules
- cytosol
- sperm tail
- Z line
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Glrx3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular iron ion homeostasis
- regulation of the force of heart contraction
- [2Fe-2S] cluster assembly
- negative regulation of cardiac muscle hypertrophy
- cell redox homeostasis
- iron-sulfur cluster assembly
Cellular Component
Where in the cell the gene product is active
- nucleus
- dendrite
- Z disc
- cytoplasm
- cell cortex
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein kinase C binding
- identical protein binding
- protein binding
- RNA binding
- metal ion binding
- iron-sulfur cluster binding