Cox15 Gene Summary [Mouse]
Predicted to enable oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor and oxidoreductase activity, acting on the CH-CH group of donors. Predicted to be involved in cytochrome complex assembly and heme A biosynthetic process. Located in mitochondrial inner membrane. Is expressed in several structures, including adipose tissue; alimentary system; eye; genitourinary system; and nervous system. Human ortholog(s) of this gene implicated in Leigh disease; hypertrophic cardiomyopathy; and mitochondrial complex IV deficiency nuclear type 6. Orthologous to human COX15 (cytochrome c oxidase assembly homolog COX15). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cox15 |
| Official Name | cytochrome c oxidase assembly protein 15 [Source:MGI Symbol;Acc:MGI:1920112] |
| Ensembl ID | ENSMUSG00000040018 |
| Bio databases IDs | |
| Aliases | cytochrome c oxidase assembly protein 15 |
| Synonyms | 2900026G05RIK, CEMCOX2, cytochrome c oxidase assembly homolog COX15, cytochrome c oxidase assembly protein 15, HAS, LOC100911779, MC4DN6 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cox15 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CH-CH group oxidoreductase
- Cytochrome oxidase assembly protein
- enzyme
- protein binding
- heme binding
Pathways
Biological processes and signaling networks where the Cox15 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- rheumatoid arthritis
- hereditary disorder
- Leigh syndrome
- insulin resistance
- fatal infantile cardioencephalomyopathy due to cytochrome C oxidase deficiency 2
- Huntington disease
- Rett syndrome
- mitochondrial disorder
- bipolar disorder
regulates
- heme
- heme a
- cytochrome
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial membrane
- mitochondrial matrix
- mitochondrial inner membrane
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cox15 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- heme biosynthetic process
- heme a biosynthetic process
- respiratory gaseous exchange
- cytochrome complex assembly
Cellular Component
Where in the cell the gene product is active
- mitochondrial respiratory chain
- mitochondrion
- cytochrome complex
- mitochondrial inner membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- cytochrome-c oxidase activity
- oxidoreductase activity, acting on the CH-CH group of donors
- metal ion binding
- oxidoreductase activity, acting on NADH or NADPH, heme protein as acceptor
- heme binding