Bex4 Gene Summary [Mouse]
Enables molecular function inhibitor activity. Involved in negative regulation of protein ubiquitination and regulation of mitotic cell cycle. Located in cytoplasm. Is expressed in several structures, including central nervous system; genitourinary system; gut; sensory organ; and submandibular gland primordium. Orthologous to human BEX4 (brain expressed X-linked 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bex4 |
| Official Name | brain expressed X-linked 4 [Source:MGI Symbol;Acc:MGI:3606746] |
| Ensembl ID | ENSMUSG00000047844 |
| Bio databases IDs | |
| Aliases | brain expressed X-linked 4 |
| Synonyms | BEXL1, brain expressed X-linked 4, brain expressed, X-linked 4, FLJ10097 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Bex4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Brain expressed X-linked like family
- alpha-tubulin binding
- histone deacetylase binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colon epithelial cancer
- metastatic colorectal cancer
- rectum cancer
- rectal adenocarcinoma
- colorectal carcinomagenesis
- peripheral arterial disease
- colon adenocarcinoma
- head and neck squamous cell carcinoma
- head and neck squamous cell cancer
- Rett syndrome
role in cell
- proliferation
- mitosis
- migration
- segregation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- microtubules
- cytosol
- nucleoplasm
- spindle pole
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Bex4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chromosome segregation
- negative regulation of protein ubiquitination
- regulation of cell migration
- regulation of cell proliferation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- spindle pole
- cytosol
- microtubule
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- histone deacetylase binding
- metal ion binding
- alpha-tubulin binding