Fem1b Gene Summary [Mouse]
Enables ubiquitin-like ligase-substrate adaptor activity. Involved in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway. Acts upstream of or within branching involved in prostate gland morphogenesis; epithelial cell maturation involved in prostate gland development; and protein ubiquitination. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; genitourinary system; liver; retina; and spleen. Used to study type 2 diabetes mellitus. Orthologous to human FEM1B (fem-1 homolog B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fem1b |
| Official Name | fem 1 homolog b [Source:MGI Symbol;Acc:MGI:1335087] |
| Ensembl ID | ENSMUSG00000032244 |
| Bio databases IDs | |
| Aliases | fem 1 homolog b |
| Synonyms | F1AA, F1A-ALPHA, F1A-α, FEM1-beta, fem-1 homolog B, FEM1-β, Feminization 1b homolog, mKIAA0396 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fem1b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- death receptor binding
- transcription regulator
- Ankyrin repeats (many copies)
- protein binding activity, bridging
- Ankyrin repeats (3 copies)
- protein binding
- Ankyrin repeat
- ankyrin repeats
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- systemic lupus erythematosus
- idiopathic pulmonary fibrosis
- systemic juvenile idiopathic arthritis
role in cell
- phosphorylation in
- apoptosis
- maturation
- survival
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- Mitochondria
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fem1b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- branching involved in prostate gland morphogenesis
- proteasomal ubiquitin-dependent protein catabolic process
- apoptotic process
- regulation of DNA damage checkpoint
- regulation of ubiquitin-protein ligase activity
- epithelial cell maturation involved in prostate gland development
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- Cul2-RING ubiquitin ligase complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- death receptor binding