Zfp473 Gene Summary [Mouse]
Predicted to enable DNA-binding transcription factor binding activity. Predicted to be involved in mRNA 3'-end processing by stem-loop binding activity and cleavage and negative regulation of transcription initiation by RNA polymerase II. Predicted to be located in Cajal body. Predicted to be active in nucleus. Is expressed in central nervous system; early conceptus; genitourinary system; and pancreas epithelium. Orthologous to human ZNF473 (zinc finger protein 473). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zfp473 |
| Official Name | zinc finger protein 473 [Source:MGI Symbol;Acc:MGI:2442697] |
| Ensembl ID | ENSMUSG00000048012 |
| Bio databases IDs | |
| Aliases | zinc finger protein 473 |
| Synonyms | D030014N22Rik, RGD1305084, ZFP100, Zfp473, zinc finger protein 473, ZN473 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Zfp473 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- krueppel associated box
- Zinc-finger double domain
- transcription factor binding
- protein binding
- KRAB (Kruppel-associated box) domain -A box
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- Cajal bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Zfp473 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- histone mRNA 3'-end processing
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- Cajal body
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription