Rnps1 Gene Summary [Mouse]
Predicted to enable mRNA 3'-UTR binding activity. Predicted to be involved in mRNA metabolic process; positive regulation of apoptotic process; and regulation of mRNA splicing, via spliceosome. Predicted to be located in nucleus. Predicted to be part of ASAP complex. Predicted to be active in cytoplasm and nucleoplasm. Is expressed in central nervous system; heart ventricle; sensory organ; thymus; and tooth. Orthologous to human RNPS1 (RNA binding protein with serine rich domain 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Rnps1 |
| Official Name | RNA binding protein with serine rich domain 1 [Source:MGI Symbol;Acc:MGI:97960] |
| Ensembl ID | ENSMUSG00000034681 |
| Bio databases IDs | |
| Aliases | RNA binding protein with serine rich domain 1 |
| Synonyms | E5.1, Ribonucleic acid binding protein S1, RNA binding protein with serine rich domain 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rnps1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- serine-rich region
- mRNA 3' UTR binding
- RNA recognition motif
- arginine/serine/proline-rich domain
- protein binding
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- systemic lupus erythematosus
- acute myeloid leukemia
- infection by HIV-1
role in cell
- expression in
- cell death
- apoptosis
- production in
- cell viability
- number
- frequency
- splicing by
- alternative splicing by
- alternative splicing in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- spliceosomes
- nucleoplasm
- interchromatin granule clusters
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rnps1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA splicing
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
- transcription, DNA-dependent
- regulation of alternative nuclear mRNA splicing, via spliceosome
- negative regulation of nuclear mRNA splicing, via spliceosome
- positive regulation of apoptotic process
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- nucleus
- exon-exon junction complex
- cytoplasm
- nuclear speck
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- mRNA 3'-UTR binding