Crebrf Gene Summary [Mouse]
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within maternal behavior; negative regulation of nuclear receptor-mediated glucocorticoid signaling pathway; and positive regulation of prolactin signaling pathway. Located in nuclear body. Is expressed in blastocyst; early embryo; polar body; and uterus. Orthologous to human CREBRF (CREB3 regulatory factor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Crebrf |
| Official Name | CREB3 regulatory factor [Source:MGI Symbol;Acc:MGI:1924378] |
| Ensembl ID | ENSMUSG00000048249 |
| Bio databases IDs | |
| Aliases | CREB3 regulatory factor |
| Synonyms | A930001N09Rik, C5orf41, CREB3 regulatory factor, LOC153222, LRF, RGD1310862 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Crebrf often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- double-stranded DNA binding
- nucleic acid binding
- protein binding
- sequence-specific DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- obesity
- dyslexia
- papillary thyroid carcinoma
- papillary thyroid cancer
- anaplastic thyroid carcinoma
- anaplastic thyroid cancer
- epithelial thyroid cancer
regulates
- DNA promoter
- DNA endogenous promoter
- RNA polymerase II
role in cell
- metabolism in
- glycolysis in
- unfolded protein response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Crebrf gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription from RNA polymerase II promoter
- response to unfolded protein
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity