Lonrf2 Gene Summary [Mouse]
Enables misfolded protein binding activity; ribonucleoprotein complex binding activity; and ubiquitin protein ligase activity. Acts upstream of or within several processes, including motor behavior; neuron differentiation; and protein quality control for misfolded or incompletely synthesized proteins. Is expressed in central nervous system; ganglia; and neural retina. Orthologous to human LONRF2 (LON peptidase N-terminal domain and ring finger 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lonrf2 |
| Official Name | LON peptidase N-terminal domain and ring finger 2 [Source:MGI Symbol;Acc:MGI:1920209] |
| Ensembl ID | ENSMUSG00000048814 |
| Bio databases IDs | |
| Aliases | LON peptidase N-terminal domain and ring finger 2 |
| Synonyms | 2900060P06Rik, LON peptidase N-terminal domain and ring finger 2, RGD1562137, RNF192 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lonrf2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ATP-dependent protease La (LON) substrate-binding domain
- RING-type zinc-finger
- ubiquitin protein ligase activity
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- zinc finger of C3HC4-type, RING
- Ring finger
- ribonucleoprotein binding
- Ring finger domain
- protein binding
- tetratricopeptide repeat
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lonrf2 gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding