Hnrnpm Gene Summary [Mouse]
Predicted to enable several functions, including calcium-dependent protein binding activity; mRNA binding activity; and protein antigen binding activity. Predicted to be involved in alternative mRNA splicing, via spliceosome; positive regulation of protein localization; and regulation of postsynapse organization. Located in collagen-containing extracellular matrix. Is active in synapse. Is expressed in several structures, including brain; genitourinary system; hemolymphoid system gland; liver; and olfactory epithelium. Orthologous to human HNRNPM (heterogeneous nuclear ribonucleoprotein M). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hnrnpm |
| Official Name | heterogeneous nuclear ribonucleoprotein M [Source:MGI Symbol;Acc:MGI:1926465] |
| Ensembl ID | ENSMUSG00000059208 |
| Bio databases IDs | |
| Aliases | heterogeneous nuclear ribonucleoprotein M |
| Synonyms | 2610023M21Rik, CEAR, Heterogeneous nuclear ribonucleoprotein m, HNRNPM4, HNRPM, HNRPM4, HTGR1, mKIAA4193, NAGR1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hnrnpm often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- calcium-dependent protein binding
- RNA recognition motif (RRM) superfamily
- RNA recognition motif
- HnRNP M nuclear localization signal
- antigen binding
- protein domain specific binding
- protein binding
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cardiovascular disorder
- coronary artery disease
- breast cancer
- metastasis
regulates
role in cell
- growth
- production in
- epithelial-mesenchymal transition
- alternative splicing by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- detergent resistant lipid raft fraction
- glutaminergic synapse
- catalytic step 2 spliceosome
- cell surface
- spliceosomes
- nuclear pores
- nucleoplasm
- nucleoli
- nuclear bodies
- nuclear rim
- interchromatin granule clusters
- nuclear envelope
- nuclear matrix
- synapse
- postsynaptic density
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hnrnpm gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- alternative nuclear mRNA splicing, via spliceosome
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- catalytic step 2 spliceosome
- paraspeckles
- membrane
- spliceosomal complex
- nuclear matrix
- synapse
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein domain specific binding
- RNA binding
- protein binding
- mRNA binding