Wnt5a Gene Summary [Mouse]
Enables frizzled binding activity; protein domain specific binding activity; and receptor ligand activity. Involved in several processes, including heart development; neuron differentiation; and positive regulation of macromolecule metabolic process. Acts upstream of or within several processes, including embryonic morphogenesis; morphogenesis of an epithelium; and reproductive structure development. Located in cell surface and extracellular matrix. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Is expressed in several structures, including alimentary system; embryo ectoderm; genitourinary system; limb; and sensory organ. Used to study Robinow syndrome. Human ortholog(s) of this gene implicated in autosomal dominant Robinow syndrome 1. Orthologous to human WNT5A (Wnt family member 5A). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Wnt5a |
| Official Name | wingless-type MMTV integration site family, member 5A [Source:MGI Symbol;Acc:MGI:98958] |
| Ensembl ID | ENSMUSG00000021994 |
| Bio databases IDs | |
| Aliases | wingless-type MMTV integration site family, member 5A |
| Synonyms | 8030457G12Rik, FLJ11441, hWNT5A, LOC102724616, wingless-type MMTV integration site family, member 5A, Wnt family member 5A |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Wnt5a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phospholipid binding
- Wnt
- frizzled binding
- chemoattractant
- wnt family
- receptor tyrosine kinase-like orphan receptor binding
- protein domain specific binding
- protein binding
- receptor binding
- cytokine
- growth factor
- found in Wnt-1
Pathways
Biological processes and signaling networks where the Wnt5a gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Adipogenesis pathway
- Axonal Guidance Signaling
- Basal Cell Carcinoma Signaling
- Chronic Myeloid Leukemia Signaling
- Colorectal Cancer Metastasis Signaling
- Factors Promoting Cardiogenesis in Vertebrates
- Glioblastoma Multiforme Signaling
- Human Embryonic Stem Cell Pluripotency
- Molecular Mechanisms of Cancer
- Ovarian Cancer Signaling
- PCP pathway
- Regulation of the Epithelial-Mesenchymal Transition Pathway
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
- Role of WNT/GSK-3β Signaling in the Pathogenesis of Influenza
- Transcriptional Regulatory Network in Embryonic Stem Cells
- Wnt/Ca+ pathway
- WNT/β-catenin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- asthma
- dysplasia
- cancer
- chronic neuropathic pain
- rheumatoid arthritis
- uterine neoplasm
- skin basal cell carcinoma
- basal cell skin cancer
role in cell
- apoptosis
- activation in
- proliferation
- phosphorylation in
- migration
- expression in
- growth
- production in
- depolarization
- adhesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Golgi lumen
- glutaminergic synapse
- endocytic vesicle membrane
- cell surface
- Plasma Membrane
- endoplasmic reticulum lumen
- synapse
- extracellular matrix
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Wnt5a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of response to cytokine stimulus
- positive regulation of JUN kinase activity
- regulation of branching involved in mammary gland duct morphogenesis
- midgut development
- planar cell polarity pathway involved in neural tube closure
- male gonad development
- positive regulation of endocytosis
- protein localization
- axon guidance
- JNK cascade
- lens development in camera-type eye
- positive regulation of NF-kappaB transcription factor activity
- positive regulation of angiogenesis
- mesodermal to mesenchymal transition involved in gastrulation
- positive regulation of anagen
- inflammatory response
- negative regulation of transcription, DNA-dependent
- kidney development
- positive regulation of transcription, DNA-dependent
- positive regulation of interferon-gamma production
- heart looping
- positive regulation of chemokine production
- positive regulation of peptidyl-serine phosphorylation
- epithelial cell proliferation involved in mammary gland duct elongation
- genitalia development
- anterior/posterior axis specification, embryo
- cochlea morphogenesis
- positive regulation of protein kinase C activity
- positive regulation of inflammatory response
- mesenchymal-epithelial cell signaling
- lateral sprouting involved in mammary gland duct morphogenesis
- positive regulation of ossification
- negative regulation of epithelial cell proliferation
- positive regulation of T cell chemotaxis
- epithelial to mesenchymal transition
- regulation of inflammatory response
- planar cell polarity pathway involved in pericardium morphogenesis
- positive regulation of protein kinase C signaling cascade
- planar cell polarity pathway involved in cardiac muscle tissue morphogenesis
- regulation of I-kappaB kinase/NF-kappaB cascade
- positive regulation of transcription from RNA polymerase II promoter
- convergent extension involved in axis elongation
- convergent extension involved in organogenesis
- negative regulation of melanin biosynthetic process
- cellular response to calcium ion
- positive regulation of fibroblast proliferation
- positive regulation of endothelial cell migration
- epithelial cell migration
- activation of protein kinase B activity
- positive regulation of meiosis
- atrial septum development
- positive regulation of MAPK cascade
- embryonic skeletal system development
- planar cell polarity pathway involved in gastrula mediolateral intercalation
- planar cell polarity pathway involved in outflow tract morphogenesis
- planar cell polarity pathway involved in ventricular septum morphogenesis
- type B pancreatic cell development
- planar cell polarity pathway involved in cardiac right atrium morphogenesis
- negative regulation of BMP signaling pathway
- olfactory bulb interneuron development
- cellular response to retinoic acid
- cell fate commitment
- hemopoietic stem cell proliferation
- positive regulation of peptidyl-threonine phosphorylation
- positive regulation of endothelial cell proliferation
- positive regulation of apoptotic signaling pathway
- negative regulation of fibroblast growth factor receptor signaling pathway
- fibroblast growth factor receptor signaling pathway
- negative regulation of prostatic bud formation
- face development
- embryonic digit morphogenesis
- planar cell polarity pathway involved in axis elongation
- wound healing
- BMP signaling pathway
- positive regulation of macrophage activation
- thymocyte apoptotic process
- optic cup formation involved in camera-type eye development
- Wnt receptor signaling pathway
- positive regulation of thymocyte apoptotic process
- positive regulation of neuron projection development
- positive regulation of tumor necrosis factor production
- negative regulation of synapse assembly
- urinary bladder development
- regulation of synapse organization
- neuron differentiation
- positive regulation of non-canonical Wnt receptor signaling pathway
- Wnt receptor signaling pathway, calcium modulating pathway
- positive regulation of protein catabolic process
- positive regulation of mesenchymal cell proliferation
- negative regulation of axon extension involved in axon guidance
- axon extension involved in axon guidance
- keratinocyte differentiation
- positive regulation of cytokine production involved in immune response
- cellular response to transforming growth factor beta stimulus
- primary heart field specification
- positive regulation of interleukin-8 production
- secondary heart field specification
- notochord morphogenesis
- somitogenesis
- positive regulation of gene expression
- hypophysis morphogenesis
- macrophage derived foam cell differentiation
- positive regulation of interleukin-6 production
- mesenchymal cell proliferation
- positive regulation of cell-cell adhesion mediated by cadherin
- cartilage development
- cervix development
- positive regulation of cartilage development
- vagina development
- positive regulation of type I interferon-mediated signaling pathway
- uterus development
- mammary gland branching involved in thelarche
- positive regulation of macrophage cytokine production
- paraxial mesoderm formation
- negative regulation of mesenchymal cell proliferation
- establishment of epithelial cell apical/basal polarity
- canonical Wnt receptor signaling pathway
- Wnt receptor signaling pathway, planar cell polarity pathway
- lung development
- negative regulation of fat cell differentiation
- hindgut morphogenesis
- negative regulation of canonical Wnt receptor signaling pathway
- cellular response to lipopolysaccharide
- negative regulation of apoptotic process
- positive regulation of JNK cascade
- establishment of planar polarity
- cellular response to interferon-gamma
- non-canonical Wnt receptor signaling pathway
- primitive streak formation
- positive regulation of interleukin-1 beta production
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular space
- clathrin-coated endocytic vesicle membrane
- extracellular vesicular exosome
- extracellular region
- Golgi lumen
- plasma membrane
- endocytic vesicle membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- frizzled binding
- protein domain specific binding
- protein binding
- receptor agonist activity
- cytokine activity
- phospholipid binding
- receptor tyrosine kinase-like orphan receptor binding