Iba57 Gene Summary [Mouse]
Predicted to enable transferase activity. Predicted to be involved in iron-sulfur cluster assembly. Located in mitochondrion. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 74 and multiple mitochondrial dysfunctions syndrome 3. Orthologous to human IBA57 (iron-sulfur cluster assembly factor IBA57). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Iba57 |
| Official Name | IBA57 homolog, iron-sulfur cluster assembly [Source:MGI Symbol;Acc:MGI:3041174] |
| Ensembl ID | ENSMUSG00000049287 |
| Bio databases IDs | |
| Aliases | IBA57 homolog, iron-sulfur cluster assembly |
| Synonyms | 4930543L23RIK, A230051G13Rik, C1orf69, IBA57 homolog, iron-sulfur cluster assembly, IBA57 homolog, iron-sulphur cluster assembly, iron-sulfur cluster assembly factor IBA57, iron-sulphur cluster assembly factor IBA57, LOC100363222, LOC100862303, LOC364802, MMDS3, RGD1306000, SPG74 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Iba57 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- folate-binding protein YgfZ
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Iba57 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- heme biosynthetic process
- iron-sulfur cluster assembly
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- transferase activity