Mtpn Gene Summary [Mouse]
Predicted to enable sequence-specific DNA binding activity. Predicted to be involved in several processes, including positive regulation of cardiac muscle hypertrophy; regulation of barbed-end actin filament capping; and regulation of macromolecule metabolic process. Predicted to be located in axon and cytosol. Predicted to be part of F-actin capping protein complex. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Used to study congestive heart failure and hypertrophic cardiomyopathy. Orthologous to human MTPN (myotrophin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mtpn |
| Official Name | myotrophin [Source:MGI Symbol;Acc:MGI:99445] |
| Ensembl ID | ENSMUSG00000029840 |
| Bio databases IDs | |
| Aliases | myotrophin |
| Synonyms | 5033418D15Rik, Beta-dg, GCDP, MYOTROPHIN, Scid complementing gene 2, V-1, β-dg |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mtpn often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- Ankyrin repeats (many copies)
- Ankyrin repeats (3 copies)
- protein binding
- sequence-specific DNA binding
- Ankyrin repeat
- ankyrin repeats
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
role in cell
- differentiation
- growth
- size
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- cell surface
- cytosol
- growth cone
- axons
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mtpn gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cerebellar granule cell differentiation
- neuron differentiation
- regulation of cell size
- catecholamine metabolic process
- positive regulation of NF-kappaB transcription factor activity
- skeletal muscle tissue regeneration
- regulation of translation
- positive regulation of protein metabolic process
- positive regulation of cell growth
- cellular response to mechanical stimulus
- striated muscle cell differentiation
- regulation of barbed-end actin filament capping
- positive regulation of cardiac muscle hypertrophy
- positive regulation of macromolecule biosynthetic process
- regulation of striated muscle tissue development
Cellular Component
Where in the cell the gene product is active
- nucleus
- perinuclear region of cytoplasm
- cytoplasm
- cytosol
- F-actin capping protein complex
- axon
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding