Gtf2e2

Predicted to enable RNA polymerase II general transcription initiation factor activity. Predicted to contribute to TFIIH-class transcription factor complex binding activity. Predicted to be involved in transcription initiation at RNA polymerase II promoter. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of transcription factor TFIID complex and transcription factor TFIIE complex. Is expressed in several structures, including blastocyst; central nervous system; foregut; genitourinary system; and liver lobe. Human ortholog(s) of this gene implicated in nonphotosensitive trichothiodystrophy 6. Orthologous to human GTF2E2 (general transcription factor IIE subunit 2). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gtf2e2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Gtf2e2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the mouse Gtf2e2 gene, providing context for its role in the cell.