Gemin4 Gene Summary [Mouse]
Predicted to enable ribonucleoprotein complex binding activity. Predicted to be involved in spliceosomal snRNP assembly. Predicted to be located in Cajal body; cytosol; and nucleolus. Predicted to be part of SMN complex. Is expressed in brain and spinal cord. Human ortholog(s) of this gene implicated in alcohol dependence and neurodevelopmental disorder with microcephaly, cataracts, and renal abnormalities. Orthologous to human GEMIN4 (gem nuclear organelle associated protein 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gemin4 |
| Official Name | gem nuclear organelle associated protein 4 [Source:MGI Symbol;Acc:MGI:2449313] |
| Ensembl ID | ENSMUSG00000049396 |
| Bio databases IDs | |
| Aliases | gem nuclear organelle associated protein 4 |
| Synonyms | 4932415L08Rik, AU015359, gem (nuclear organelle) associated protein 4, gem nuclear organelle associated protein 4, HC56, HCAP1, HHRF-1, NEDMCR, p97, RGD1563715 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gemin4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ribonucleoprotein binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- renal cell carcinoma
- neurodevelopmental disorder with microcephaly, cataracts and renal abnormalities
- renal cell cancer
- colon carcinoma
- colon epithelial cancer
- adult T-cell leukemia/lymphoma
- mature T-cell neoplasia
- T-cell non-Hodgkin disease
regulated by
- lipopolysaccharide
- THP-1 cells
- mir-27 (includes others)
- HeLa cells
- bee venom
- mir-23 (includes others)
regulates
- BCL2L1
- snRNP
role in cell
- alternative splicing in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- polyribosome fractions
- Cytoplasm
- cytosol
- gems
- nucleoplasm
- nucleoli
- nuclear bodies
- Cajal bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gemin4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- rRNA processing
- spliceosomal snRNP assembly
Cellular Component
Where in the cell the gene product is active
- nuclear body
- extracellular vesicular exosome
- cytoplasm
- SMN-Sm protein complex
- membrane
- Cajal body
- cytosol
- small nuclear ribonucleoprotein complex
- nucleolus
- SMN complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- ribonucleoprotein complex binding