Tmx2 Gene Summary [Mouse]
Predicted to enable disulfide oxidoreductase activity and identical protein binding activity. Predicted to be involved in brain development. Predicted to be located in mitochondrial membrane. Predicted to be active in endoplasmic reticulum membrane; mitochondria-associated endoplasmic reticulum membrane contact site; and mitochondrion. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; hemolymphoid system; and nervous system. Orthologous to human TMX2 (thioredoxin related transmembrane protein 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tmx2 |
| Official Name | thioredoxin-related transmembrane protein 2 [Source:MGI Symbol;Acc:MGI:1914208] |
| Ensembl ID | ENSMUSG00000050043 |
| Bio databases IDs | |
| Aliases | thioredoxin-related transmembrane protein 2 |
| Synonyms | 2310042M24RIK, CGI-31, NEDMCMS, PDIA12, PIG26, thioredoxin-related transmembrane protein 2, TXNDC14 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tmx2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- disulfide oxidoreductase
- Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
- enzyme
- protein binding
- identical protein binding
- thioredoxin
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- liver cancer
- epithelial cancer
- neurodevelopmental disorder with microcephaly, cortical malformations and spasticity
- hepatocellular carcinoma
- pervasive developmental disorder
- anxiety disorder
role in cell
- survival
- dipeptide repeat protein sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- endoplasmic reticulum mitochondria contact site
- Mitochondria
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tmx2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- brain development
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- mitochondrial membrane
- mitochondrion
- ER-mitochondrion membrane contact site
- membrane-bounded organelle
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- disulfide oxidoreductase activity
- protein binding