Ptpn1 Gene Summary [Mouse]
Enables protein tyrosine phosphatase activity. Involved in several processes, including IRE1-mediated unfolded protein response; peptidyl-tyrosine dephosphorylation; and regulation of signal transduction. Acts upstream of or within insulin receptor signaling pathway and protein dephosphorylation. Located in early endosome and sorting endosome. Is active in endosome lumen. Is expressed in central nervous system; midbrain; and superior colliculus. Human ortholog(s) of this gene implicated in coronary artery disease; essential hypertension; and type 2 diabetes mellitus. Orthologous to human PTPN1 (protein tyrosine phosphatase non-receptor type 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ptpn1 |
| Official Name | protein tyrosine phosphatase, non-receptor type 1 [Source:MGI Symbol;Acc:MGI:97805] |
| Ensembl ID | ENSMUSG00000027540 |
| Bio databases IDs | |
| Aliases | protein tyrosine phosphatase, non-receptor type 1 |
| Synonyms | protein-TYROSINE PHOSPHATASE, protein tyrosine phosphatase non-receptor type 1, protein tyrosine phosphatase, non-receptor type 1, Ptp, PTP-1B, PTP1B alpha, PTP1BB, PTP1B α, Ptpase 1, PTPASE 1B, PTP-HA2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ptpn1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- insulin receptor binding
- Akt phosphorylation site
- protein kinase binding
- protein-tyrosine-phoshatase
- COP1 binding motif
- catalytic domain
- protein phosphatase binding
- Protein tyrosine phosphatase, catalytic domain
- enzyme binding
- ephrin receptor binding
- PTP_DSP_cys
- protein binding
- receptor binding
- Protein tyrosine phosphatase, catalytic domain motif
- Sh3 domain binding motif
- Protein tyrosine phosphatase, catalytic domain, undefined specificity
- Protein-tyrosine phosphatase
- zinc ion binding
- receptor tyrosine kinase binding
- phosphatase
Pathways
Biological processes and signaling networks where the Ptpn1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- rheumatoid arthritis
- systemic lupus erythematosus
- cancer
- epithelial neoplasia
- epithelial cancer
- neoplastic cell transformation
- diabetes mellitus
- obesity
- experimentally-induced diabetes
- impaired glucose tolerance
role in cell
- phosphorylation in
- tyrosine phosphorylation in
- apoptosis
- migration
- growth
- proliferation
- survival
- degradation in
- activation in
- expression in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- endoplasmic reticulum mitochondria contact site
- perinuclear region
- postsynaptic region
- cellular membrane
- Plasma Membrane
- endosomes
- Endoplasmic Reticulum
- Mitochondria
- cytosol
- endoplasmic reticulum membrane
- mitochondrial cristae
- mitochondrial matrix
- mitochondrial inner membrane
- early endosomes
- membrane rafts
- sorting endosomes
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ptpn1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- JAK-STAT cascade involved in growth hormone signaling pathway
- positive regulation of JUN kinase activity
- negative regulation of MAP kinase activity
- insulin receptor signaling pathway
- positive regulation of protein tyrosine kinase activity
- platelet-derived growth factor receptor-beta signaling pathway
- protein dephosphorylation
- regulation of type I interferon-mediated signaling pathway
- insulin receptor recycling
- regulation of signal transduction
- negative regulation of insulin receptor signaling pathway
- negative regulation of signal transduction
- positive regulation of receptor catabolic process
- endoplasmic reticulum unfolded protein response
- negative regulation of ERK1 and ERK2 cascade
- negative regulation of vascular endothelial growth factor receptor signaling pathway
- cellular response to unfolded protein
- regulation of intracellular protein transport
- regulation of endocytosis
- actin cytoskeleton organization
- peptidyl-tyrosine dephosphorylation
Cellular Component
Where in the cell the gene product is active
- early endosome
- cytoplasm
- mitochondrial matrix
- mitochondrial crista
- endosome lumen
- cytosol
- endoplasmic reticulum
- macromolecular complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- zinc ion binding
- ephrin receptor binding
- insulin receptor binding
- protein binding
- RNA binding
- non-membrane spanning protein tyrosine phosphatase activity
- protein tyrosine phosphatase activity
- cadherin binding
- receptor tyrosine kinase binding
- protein phosphatase 2A binding
- enzyme binding