Htr1f Gene Summary [Mouse]
Predicted to enable G protein-coupled serotonin receptor activity; neurotransmitter receptor activity; and serotonin binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; adenylate cyclase-inhibiting serotonin receptor signaling pathway; and chemical synaptic transmission. Predicted to be active in dendrite and plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and mammary gland. Orthologous to human HTR1F (5-hydroxytryptamine receptor 1F). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Htr1f |
| Official Name | 5-hydroxytryptamine (serotonin) receptor 1F [Source:MGI Symbol;Acc:MGI:99842] |
| Ensembl ID | ENSMUSG00000050783 |
| Bio databases IDs | |
| Aliases | 5-hydroxytryptamine (serotonin) receptor 1F |
| Synonyms | 5-HT-1F, 5HT6, 5-hydroxytryptamine receptor 1F, 5-hydroxytryptamine (serotonin) receptor 1F, Htr1eb, HTR1EL, MR77 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Htr1f often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- 5-HT1 receptor
- serotonin receptor
- serotonin binding
- 7 transmembrane receptor (rhodopsin family)
- seven-transmembrane G protein-coupled receptor superfamily
- transmembrane receptor
Pathways
Biological processes and signaling networks where the Htr1f gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- 5-hydroxytryptamine
- ergotamine
- lasmiditan
- olanzapine
- rizatriptan
- eletriptan
- almotriptan
- fenfluramine
- zolmitriptan
- naratriptan
disease
- weight gain
- chemotherapy sickness
- anxiety disorder
- major depression
- schizophrenia
- migraines
- depressive disorder
- bipolar disorder
- bipolar I disorder
- severe myoclonic epilepsy in infancy
regulated by
- 5-hydroxytryptamine
- ANXA7
- sumatriptan
- fluoxetine
- nortriptyline
- olanzapine
- buspirone
- risperidone
- methysergide
- quetiapine
regulates
- ADCY
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Htr1f gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
- adenylate cyclase-inhibiting serotonin receptor signaling pathway
- synaptic transmission
Cellular Component
Where in the cell the gene product is active
- dendrite
- synapse
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- serotonin binding
- neurotransmitter receptor activity
- serotonin receptor activity