Anxa7 Gene Summary [Mouse]
Enables GTPase-dependent fusogenic activity. Acts upstream of or within with a positive effect on ligand-gated ion channel signaling pathway; phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway; and positive regulation of insulin secretion. Acts upstream of or within several processes, including glial cell proliferation; intracellular calcium ion homeostasis; and intracellular water homeostasis. Located in several cellular components, including cytosol; nuclear envelope; and vesicle. Orthologous to human ANXA7 (annexin A7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Anxa7 |
| Official Name | annexin A7 [Source:MGI Symbol;Acc:MGI:88031] |
| Ensembl ID | ENSMUSG00000021814 |
| Bio databases IDs | |
| Aliases | annexin A7 |
| Synonyms | annexin A7, ANX7, SNX, SYNEXIN |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Anxa7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Formin Homology Region 1
- calcium-dependent protein binding
- integrin binding
- calcium-dependent phospholipid binding
- GTPase
- Annexin
- protein binding
- ion channel
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- neoplasia
- epithelial cancer
- epithelial neoplasia
- liver neoplasia
- colorectal cancer
- abdominal cancer
- digestive system cancer
- tumorigenesis
- liver cancer
regulated by
- PKC
- PKA catalytic subunit
- ZBM-H
- EGF
- PKG
- AR-A014418
- long-term hematopoietic stem cells
- tetradecanoylphorbol acetate
- Ca2+
- lipopolysaccharide
role in cell
- apoptosis
- expression in
- colony formation
- proliferation
- invasion by
- migration
- adhesion
- epithelial-mesenchymal transition
- growth
- aggregation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- endoplasmic reticulum mitochondria contact site
- Cytoplasm
- Nucleus
- vesicles
- secretory granule membrane
- cytosol
- endoplasmic reticulum membrane
- nucleoplasm
- nuclear envelope
- neurites
- exosomes
- apical processes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Anxa7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- epithelial cell differentiation
- negative regulation of gene expression
- autophagy
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nucleus
- extracellular vesicular exosome
- cytoplasm
- vesicle membrane
- membrane
- chromaffin granule membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- phosphatidylserine binding
- RNA binding
- protein binding
- calcium ion binding
- calcium-dependent protein binding
- integrin binding
- calcium-dependent phospholipid binding