Hs6st3 Gene Summary [Mouse]
Enables heparan sulfate 6-sulfotransferase activity. Involved in heparan sulfate proteoglycan biosynthetic process. Is active in Golgi apparatus. Is expressed in several structures, including central nervous system; future brain; genitourinary system; limb primordium; and sensory organ. Orthologous to human HS6ST3 (heparan sulfate 6-O-sulfotransferase 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hs6st3 |
| Official Name | heparan sulfate 6-O-sulfotransferase 3 [Source:MGI Symbol;Acc:MGI:1354960] |
| Ensembl ID | ENSMUSG00000053465 |
| Bio databases IDs | |
| Aliases | heparan sulfate 6-O-sulfotransferase 3 |
| Synonyms | 6OST3, heparan sulfate 6-O-sulfotransferase 3, heparan sulphate 6-O-sulphotransferase 3, LOC100134314, LOC100509010, LOC100653112, LOC100909908, LOC283476, RGD1560050 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hs6st3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- sulfotransferase
- heparan sulfate 6-O-sulfotransferase
- enzyme
- Sulfotransferase family
Pathways
Biological processes and signaling networks where the Hs6st3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- major depression
- schizophrenia
- non-insulin-dependent diabetes mellitus
- breast cancer
- obesity
- metabolic syndrome X
- insomnia
- epithelial ovarian cancer
- refractive error
- diabetic retinopathy
regulated by
- Bt 549 cells
regulates
- heparan sulfate proteoglycan
- HS6ST1
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Golgi Apparatus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hs6st3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- heparan sulfate proteoglycan biosynthetic process, enzymatic modification
Cellular Component
Where in the cell the gene product is active
- membrane
- Golgi apparatus
Molecular Function
What the gene product does at the molecular level
- heparan sulfate 6-O-sulfotransferase activity