Rnf212 Gene Summary [Mouse]
Predicted to enable SUMO transferase activity. Involved in chiasma assembly and meiotic gene conversion. Colocalizes with synaptonemal complex. Human ortholog(s) of this gene implicated in spermatogenic failure 62. Orthologous to human RNF212 (ring finger protein 212). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Rnf212 |
| Official Name | ring finger protein 212 [Source:MGI Symbol;Acc:MGI:3645767] |
| Ensembl ID | ENSMUSG00000055385 |
| Bio databases IDs | |
| Aliases | ring finger protein 212 |
| Synonyms | EG330157, F830003B07, LOC100132787, repro57, ring finger protein 212, SPGF62, ZHP3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rnf212 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SUMO transferase activity
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- enzyme
- zinc-RING finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromatin foci
- synaptonemal complexes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rnf212 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chiasma assembly
- reciprocal meiotic recombination
- protein sumoylation
- meiotic gene conversion
- synapsis
Cellular Component
Where in the cell the gene product is active
- synaptonemal complex
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- SUMO ligase activity