Apol8 Gene Summary [Mouse]
Predicted to enable chloride channel activity and lipid binding activity. Predicted to be located in extracellular space and intracellular membrane-bounded organelle. Predicted to be part of high-density lipoprotein particle and very-low-density lipoprotein particle. Is expressed in liver. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to several human genes including APOL1 (apolipoprotein L1) and APOL2 (apolipoprotein L2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Apol8 |
| Official Name | apolipoprotein L 8 [Source:MGI Symbol;Acc:MGI:2444921] |
| Ensembl ID | ENSMUSG00000056656 |
| Bio databases IDs | |
| Aliases | apolipoprotein L 8 |
| Synonyms | 9830006J20Rik, Apol2, APOL-II, apolipoprotein L2, apolipoprotein L 8, LOC100911804 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Apol8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- lipid binding
- chloride channel
- Apolipoprotein L
- ion channel
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- intracellular membrane-bounded organelle