Mecp2 Gene Summary [Mouse]
Enables several functions, including DNA binding activity; RNA binding activity; and promoter-specific chromatin binding activity. Involved in several processes, including associative learning; negative regulation of smooth muscle cell differentiation; and negative regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including learning or memory; nervous system development; and regulation of gene expression. Located in cytosol; heterochromatin; and nucleus. Is expressed in several structures, including alimentary system; early conceptus; nervous system; paraxial mesenchyme; and sensory organ. Used to study Rett syndrome. Human ortholog(s) of this gene implicated in Rett syndrome; autistic disorder; gastrointestinal system disease; severe congenital encephalopathy due to MECP2 mutation; and syndromic X-linked intellectual disability (multiple). Orthologous to human MECP2 (methyl-CpG binding protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mecp2 |
| Official Name | methyl CpG binding protein 2 [Source:MGI Symbol;Acc:MGI:99918] |
| Ensembl ID | ENSMUSG00000031393 |
| Bio databases IDs | |
| Aliases | methyl CpG binding protein 2 |
| Synonyms | 1500041B07Rik, AUTSX3, D630021H01RIK, Mbd5, Mecp2 Beta, Mecp2 β, methyl-CpG binding protein 2, MRX16, MRX79, MRXS13, MRXSL, PPMX, RS, RTS, RTT, WBP10 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mecp2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- DNA binding domain
- nucleic acid binding
- mRNA binding
- transcription co-repressor
- DNA secondary structure binding
- protein binding activity, bridging
- enzyme binding
- transcription factor binding
- histone deacetylase binding
- chromatin binding
- protein domain specific binding
- protein binding
- identical protein binding
- DNA binding
- RNA binding
- unmethylated CpG binding
- transcription repression domain
- double-stranded DNA binding
- NCoR/SMRT interaction domain
- methyl-CpG binding
- corepressor binding domain
- AT hook domain
- MBD
Pathways
Biological processes and signaling networks where the Mecp2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- attention deficit hyperactivity disorder
- schizophrenia
- epilepsy
- seizures
- pain
- ataxia
- weight gain
- COVID-19
- obesity
- Rett syndrome
phenotypes
- abnormal action potential
- abnormal associative learning
- abnormal behavior
- abnormal body temperature
- abnormal body weight
- abnormal brain development
- abnormal brain wave pattern
- abnormal breathing pattern
- abnormal cell nucleus morphology
- abnormal cerebellar granule layer morphology
- abnormal cerebellum morphology
- abnormal cerebral cortex morphology
- abnormal contextual conditioning behavior
- abnormal cued conditioning behavior
- abnormal dendrite morphology
- abnormal dentate gyrus morphology
- abnormal dosage compensation by inactivation of X chromosome
- abnormal excitatory postsynaptic currents
- abnormal excitatory postsynaptic potential
- abnormal fear/anxiety-related behavior
- abnormal gait
- abnormal hearing physiology
- abnormal heart rate
- abnormal heartbeat
- abnormal hippocampus CA2 region morphology
- abnormal hippocampus morphology
- abnormal hippocampus neuron morphology
- abnormal hippocampus physiology
- abnormal jaw morphology
- abnormal locomotor activation
- abnormal locomotor behavior
- abnormal locomotor coordination
- abnormal long term object recognition memory
- abnormal miniature excitatory postsynaptic currents
- abnormal miniature inhibitory postsynaptic currents
- abnormal motor capabilities/coordination/movement
- abnormal motor coordination/ balance
- abnormal motor learning
- abnormal nervous system electrophysiology
- abnormal nervous system physiology
- abnormal nest building behavior
- abnormal neuron morphology
- abnormal neurotransmitter level
- abnormal olfactory bulb morphology
- abnormal orbitofrontal cortex morphology
- abnormal parasympathetic nervous system physiology
- abnormal pilomotor reflex
- abnormal placenta morphology
- abnormal respiration
- abnormal response to novel object
- abnormal response to novelty
- abnormal social investigation
- abnormal sympathetic nervous system physiology
- abnormal synaptic vesicle number
- abnormal tooth morphology
- abnormal touch/ nociception
- abnormal vibrissa morphology
- akinesia
- apnea
- ataxia
- atrioventricular block
- cachexia
- cryptorchism
- decreased CNS synapse formation
- decreased anxiety-related response
- decreased body temperature
- decreased body weight
- decreased brain size
- decreased brain weight
- decreased grip strength
- decreased heart rate
- decreased neuron number
- decreased noradrenaline level
- decreased prepulse inhibition
- decreased serotonin level
- decreased startle reflex
- decreased vertical activity
- disheveled coat
- focal hair loss
- greasy coat
- hyperactivity
- hypoactivity
- impaired contextual conditioning behavior
- impaired coordination
- impaired cued conditioning behavior
- increased anxiety-related response
- increased body weight
- increased brain cholesterol level
- increased brain weight
- increased circulating LDL cholesterol level
- increased circulating cholesterol level
- increased circulating triglyceride level
- increased fear-related response
- increased grooming behavior
- increased heart rate variability
- increased heart weight
- increased liver triglyceride level
- increased liver weight
- increased placenta apoptosis
- increased pulmonary respiratory rate
- increased response of heart to induced stress
- increased stereotypic behavior
- increased susceptibility to age related obesity
- increased susceptibility to pharmacologically induced seizures
- increased thermal nociceptive threshold
- increased total fat pad weight
- increased vertical activity
- irregular heartbeat
- kyphosis
- lethargy
- limb grasping
- male infertility
- malocclusion
- no abnormal phenotype detected
- obese
- postnatal growth retardation
- premature death
- preweaning lethality incomplete penetrance
- prolonged QT interval
- reduced long term potentiation
- respiratory distress
- ruffled hair
- seizures
- short stride length
- skin lesions
- slow postnatal weight gain
- sporadic seizures
- stereotypic behavior
- tachypnea
- tonic-clonic seizures
- tremors
- ventricular premature beat
- weight loss
role in cell
- apoptosis
- cell death
- expression in
- proliferation
- activation in
- fragmentation
- binding in
- migration
- quantity
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- glutaminergic synapse
- heterochromatin
- Cytoplasm
- centrosome
- cytosol
- nuclear foci
- chromosome
- nucleoplasm
- nucleoli
- spindle pole
- chromatin
- pericentric heterochromatin
- heterochromatic compartments
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mecp2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of angiogenesis
- post-embryonic development
- protein localization
- negative regulation of astrocyte differentiation
- visual learning
- adult locomotory behavior
- striatum development
- regulation of respiratory gaseous exchange by neurological system process
- thalamus development
- spinal cord development
- lung alveolus development
- response to hypoxia
- catecholamine secretion
- negative regulation of transcription, DNA-dependent
- negative regulation of primary miRNA processing
- positive regulation of synaptic plasticity
- cardiolipin metabolic process
- long-term synaptic potentiation
- response to ionizing radiation
- regulation of excitatory postsynaptic membrane potential
- regulation of synapse organization
- cerebellum development
- negative regulation of dendritic spine development
- response to cocaine
- positive regulation of dendritic spine development
- positive regulation of microtubule nucleation
- respiratory gaseous exchange
- cerebral cortex development
- principal sensory nucleus of trigeminal nerve development
- cellular biogenic amine metabolic process
- long-term memory
- ventricular system development
- negative regulation of gene expression
- synapse assembly
- phosphatidylcholine metabolic process
- Notch signaling pathway
- proprioception
- heterochromatin assembly
- response to estradiol stimulus
- sensory perception of pain
- gene expression
- cellular response to potassium ion
- oligodendrocyte development
- inositol metabolic process
- response to other organism
- glutamine metabolic process
- neuron maturation
- negative regulation of smooth muscle cell differentiation
- positive regulation of transcription from RNA polymerase II promoter
- olfactory bulb development
- negative regulation of neuron apoptotic process
- negative regulation of transcription from RNA polymerase II promoter
- startle response
- ventricular cardiac muscle tissue development
- genetic imprinting
- cellular response to isoquinoline alkaloid
- dendrite development
- social behavior
- negative regulation of blood vessel endothelial cell migration
- negative regulation of locomotion involved in locomotory behavior
- positive regulation of glial cell proliferation
- hippocampus development
- hypermethylation of CpG island
- glucocorticoid metabolic process
- behavioral fear response
- neurological system process involved in regulation of systemic arterial blood pressure
- glial cell proliferation
- response to lead ion
Cellular Component
Where in the cell the gene product is active
- nucleus
- heterochromatin
- centrosome
- extracellular space
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- chromatin DNA binding
- protein domain specific binding
- double-stranded methylated DNA binding
- identical protein binding
- histone deacetylase binding
- siRNA binding
- unmethylated CpG binding
- chromatin binding
- methyl-CpG binding
- four-way junction DNA binding
- nucleic acid binding
- DNA binding
- RNA binding
- protein binding
- transcription corepressor activity
- mRNA binding
- binding, bridging