Tcf20 Gene Summary [Mouse]
Enables minor groove of adenine-thymine-rich DNA binding activity; transcription cis-regulatory region binding activity; and transcription coactivator activity. Involved in positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including branchial arch; central nervous system; early conceptus; genitourinary system; and sensory organ. Used to study Phelan-McDermid syndrome and autism spectrum disorder. Orthologous to human TCF20 (transcription factor 20). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tcf20 |
| Official Name | transcription factor 20 [Source:MGI Symbol;Acc:MGI:108399] |
| Ensembl ID | ENSMUSG00000041852 |
| Bio databases IDs | |
| Aliases | transcription factor 20 |
| Synonyms | 2810438H08Rik, AR1, DDVIBA, mKIAA0292, SPBP, transcription factor 20 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tcf20 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PHD zinc finger
- transcription regulator
- transcription co-activator
- DNA binding domain
- nucleic acid binding
- leucine zipper domain
- protein binding
- sequence-specific DNA binding
- AT DNA binding
- PHD-like zinc-binding domain
- double-stranded DNA binding
- polyglutamine repeat
- PHD finger superfamily
- basic domain
- transcription factor activity
- PHD-zinc-finger like domain
Pathways
Biological processes and signaling networks where the Tcf20 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metabolic syndrome X
- developmental delay with variable intellectual impairment and behavioral abnormalities
- Alzheimer disease
- hereditary disorder
- schizophrenia
- major depression
- mental retardation
- pervasive developmental disorder
- craniosynostosis
- global developmental delay
role in cell
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tcf20 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- RNA binding
- metal ion binding