Slc24a3 Gene Summary [Mouse]
Enables calcium, potassium:sodium antiporter activity. Acts upstream of or within bone mineralization; intracellular calcium ion homeostasis; and regulation of gene expression. Located in cell periphery. Is expressed in several structures, including alimentary system; central nervous system; dorsal root ganglion; eye; and musculature. Orthologous to human SLC24A3 (solute carrier family 24 member 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Slc24a3 |
| Official Name | solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 [Source:MGI Symbol;Acc:MGI:2137513] |
| Ensembl ID | ENSMUSG00000063873 |
| Bio databases IDs | |
| Aliases | solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 |
| Synonyms | NCKX3, solute carrier family 24 member 3, solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slc24a3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- calcium, potassium:sodium antiporter
- Sodium/calcium exchanger protein
- K+-dependent Na+/Ca+ exchanger related-protein
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- psychosis
- COVID-19
- endometrial cancer
- myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis
- migraines
- pain
- myopia
- headache
- cataract
regulates
- Ca2+
- Na+
- K+
- ion
- cation
role in cell
- homeostasis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell periphery
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Slc24a3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of gene expression
- ion transport
- potassium ion transmembrane transport
- bone mineralization
- positive regulation of gene expression
- calcium ion transmembrane transport
- sodium ion transmembrane transport
- cellular calcium ion homeostasis
Cellular Component
Where in the cell the gene product is active
- plasma membrane
- cell periphery
Molecular Function
What the gene product does at the molecular level
- calcium channel activity
- calcium, potassium:sodium antiporter activity
- symporter activity