Slc30a5 Gene Summary [Mouse]
Predicted to enable zinc efflux transmembrane transporter activity and zinc:proton antiporter activity. Predicted to be involved in several processes, including insulin processing; intracellular zinc ion homeostasis; and zinc ion transmembrane transport. Predicted to act upstream of with a positive effect on GPI anchor biosynthetic process. Predicted to be located in several cellular components, including Golgi apparatus; cytoplasmic vesicle membrane; and nuclear lumen. Predicted to be active in Golgi apparatus and cytoplasmic vesicle. Is expressed in craniocervical region bone; submandibular gland primordium; and thoracic segment skeleton. Orthologous to human SLC30A5 (solute carrier family 30 member 5). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc30a5 |
| Official Name | solute carrier family 30 (zinc transporter), member 5 [Source:MGI Symbol;Acc:MGI:1916298] |
| Ensembl ID | ENSMUSG00000021629 |
| Bio databases IDs | |
| Aliases | solute carrier family 30 (zinc transporter), member 5 |
| Synonyms | 1810010K08Rik, FLJ12496 FIS, MGC5499, Slc30a5 predicted, solute carrier family 30 member 5, solute carrier family 30 (zinc transporter), member 5, Zip5, ZNT5, ZNTL1, ZTL1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slc30a5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- hydrogen ion transporter
- cation diffusion facilitator family transporter
- transmembrane domain
- antiporter
- protein binding
- zinc ion transporter
- Cation efflux family
- metal ion transporter
- cation efflux permease
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- kyphosis
- atrial ventricular block
- growth failure
- sinus bradycardia
- hypopigmentation
role in cell
- growth
- expression in
- quantity
- number
- stabilization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- Cytoplasm
- perinuclear region
- cellular membrane
- vesicles
- Golgi Apparatus
- Endoplasmic Reticulum
- secretory granule membrane
- basolateral cell surfaces
- endoplasmic reticulum membrane
- apical membrane
- Golgi membrane
- trans Golgi network
- nucleoplasm
- nucleoli
- cytoplasmic vesicles
- secretory granules
- Golgi cisternae
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Slc30a5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cobalt ion transport
- GPI anchor biosynthetic process
- insulin processing
- zinc ion transport
- cellular zinc ion homeostasis
- zinc ion transmembrane transport
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- secretory granule membrane
- secretory granule
- membrane
- ER to Golgi transport vesicle membrane
- cytoplasmic vesicle
- Golgi apparatus
- Golgi membrane
- nucleolus
- apical plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- antiporter activity
- metal ion binding
- zinc ion transmembrane transporter activity