Lpcat3 Gene Summary [Mouse]
Enables 1-acylglycerophosphocholine O-acyltransferase activity; 1-acylglycerophosphoethanolamine O-acyltransferase activity; and 1-acylglycerophosphoserine O-acyltransferase activity. Involved in several processes, including glycerophospholipid metabolic process; intestinal stem cell homeostasis; and plasma lipoprotein particle assembly. Acts upstream of or within regulation of plasma lipoprotein particle levels. Located in endoplasmic reticulum membrane. Is expressed in several structures, including adrenal gland; alimentary system; central nervous system; hemolymphoid system; and liver. Orthologous to human LPCAT3 (lysophosphatidylcholine acyltransferase 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Lpcat3 |
| Official Name | lysophosphatidylcholine acyltransferase 3 [Source:MGI Symbol;Acc:MGI:1315211] |
| Ensembl ID | ENSMUSG00000004270 |
| Bio databases IDs | |
| Aliases | lysophosphatidylcholine acyltransferase 3 |
| Synonyms | C3F, Grcc3f, LPCAT, Lpeat, LPLAT12, LPLAT 5, LPSAT, lysophosphatidylcholine acyltransferase 3, MBOAT5, Moact5, Nessy, OACT5, PTG |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lpcat3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 1-acylglycerol-3-phosphate O-acyltransferase
- 2-acylglycerol-3-phosphate O-acyltransferase
- MBOAT, membrane-bound O-acyltransferase family
- 1-acylglycerophosphocholine O-acyltransferase
- enzyme
- O-acyltransferase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pancreatic adenocarcinoma
- edema
- pancreatic epithelial cancer
- hypertriglyceridemia
- esophageal carcinoma formation
- renal clear cell adenocarcinoma
- renal clear cell cancer
- glioblastoma
- glioblastoma cancer
- lung adenocarcinoma
role in cell
- phosphorylation in
- activation in
- cross-sectional area
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lpcat3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- phosphatidylcholine acyl-chain remodeling
- regulation of cholesterol biosynthetic process
- phosphatidylethanolamine acyl-chain remodeling
- endoplasmic reticulum membrane organization
- negative regulation of inflammatory response
- positive regulation of intestinal cholesterol absorption
- very-low-density lipoprotein particle assembly
- chylomicron assembly
- phosphatidylserine acyl-chain remodeling
- phosphatidylcholine biosynthetic process
- lipid modification
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
Molecular Function
What the gene product does at the molecular level
- 1-acylglycerol-3-phosphate O-acyltransferase activity
- lysophospholipid acyltransferase activity
- 1-acylglycerophosphocholine O-acyltransferase activity
- 2-acylglycerol-3-phosphate O-acyltransferase activity