Syvn1 Gene Summary [Mouse]
Enables ubiquitin protein ligase activity. Involved in immature B cell differentiation; protein stabilization; and proteolysis involved in protein catabolic process. Acts upstream of or within in utero embryonic development and negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway. Located in endoplasmic reticulum quality control compartment. Is expressed in rib. Orthologous to human SYVN1 (synoviolin 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Syvn1 |
| Official Name | synovial apoptosis inhibitor 1, synoviolin [Source:MGI Symbol;Acc:MGI:1921376] |
| Ensembl ID | ENSMUSG00000024807 |
| Bio databases IDs | |
| Aliases | synovial apoptosis inhibitor 1, synoviolin |
| Synonyms | 1200010C09Rik, D530017H19Rik, DER3, HRD1, RGD1310488, synovial apoptosis inhibitor 1, synoviolin, Synoviolin, synoviolin 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Syvn1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protease binding
- catalytic domain
- ubiquitin protein ligase activity
- Ring finger domain
- protein binding
- proline rich domain
- RING-like zinc finger
- ATPase binding
- cytoplasmic domain
- RING-type zinc-finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- transmembrane domain
- chaperone binding
- RING-H2 zinc finger domain
- transporter
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Pathways
Biological processes and signaling networks where the Syvn1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- Alzheimer disease
- liver cirrhosis
- lung cancer
- collagen-induced arthritis
- skin squamous cell carcinoma
- squamous cell skin cancer
- periodontitis
- metastasis
- arthritis
role in cell
- expression in
- apoptosis
- proliferation
- quantity
- cell viability
- accumulation in
- formation in
- formation
- production in
- generation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- nucleoplasm
- smooth endoplasmatic reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Syvn1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
- protein K48-linked ubiquitination
- immature B cell differentiation
- retrograde protein transport, ER to cytosol
- protein stabilization
- ubiquitin-dependent protein catabolic process
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- Hrd1p ubiquitin ligase ERAD-L complex
- cytoplasm
- Hrd1p ubiquitin ligase complex
- smooth endoplasmic reticulum
- membrane
- endoplasmic reticulum quality control compartment
- endomembrane system
- endoplasmic reticulum
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- chaperone binding
- unfolded protein binding
- ATPase binding